Endocrine Abstracts

The action of the regulatory neuropeptides vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) carries out through the shared receptors VPAC1 and VPAC2 and the exclusive PACAP receptor PAC1, all of which are G protein-coupled receptors. Formerly, we showed that the administration of both peptides enhance catecholamine, corticosterone and aldosterone release from adrenal cell co-culture. Further...

The pituitary adenylate cyclase-activating polypeptide (PACAP), isolated for the first time from hypothalamic extracts (Miyata et al. 1989), was localized in some peripheral tissues such as adrenal, gastrointestinal tract, ovary and testis (Arimura et al. 1991, Watanabe et al. 1992, Gathei et al. 1993, Shioda et al. 1994, Kononen et al. 1994). It was previously demonstrated that in the testis PACAP was involved in the steroidogenesis r...